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The Fully Engineerable Future

The Fully Engineerable Future

The Fully Engineerable Future

Drew Endy Resources:
Rewiring Nature with Synthetic Biology, Discover
Drew Endy’s Lab
TEDx: Synthetic Biology: What should we be vibrating about?

This article comes from an edited transcript of the Arc Fusion Talk delivered by Drew Endy on April 21, 2015. Watch the video here.

The thing about the improbable is that it's not probable. And I want to share with you some wishes about the improbable. Let me go back in time to the first time I visited the Balkans. I didn't need a passport, I just had to go to Emeryville to meet with a team that was developing a drug for treating malaria –  a vertically integrated pharmaceutical startup if you will. And they had a crisis. Their funder had to spend more money right away. So they came to their advisers, of which I was one, and asked how could we spend more money on this team? 

“The problem of solving problems is the secret of how we sustain exponential improvements in our capacity to do stuff.”

And the thing that was really interesting about the project was the drug they were developing – resistance in nature to that compound had already emerged, so you could foresee that they would have to do the project again and again and again. And what was doubly amazing was how much work it was to do such a project. It was about 150 PhD years of effort just to make this one compound. And that was fine because you could afford to pay that many people. But the task of organizing the team, having the people who knew that the drug could be developed in the first place and that knew the science and the biochemistry and the genetics and how to bring it to market, that's kind of tough, organizing people to do that.

And so I gave them the best advice I could. Please invest in this team right now in making platforms so that the next time you have to do this project it's easier to do.  And I thought this was a really great idea. 

The worst advice I'd ever given. 

The team said no way and the money said no way. The only way we'll spend more money or take more money, both parties said, was if we bring this drug to market one week earlier because every week we delay this many more people have died. 

Since then I've helped start biological engineering at MIT and at Stanford, Imogen and Biobricks and so on.  Tomorrow I have to go to Stanford and I have to teach the first year undergraduates introduction to bioengineering which we've renamed “engineering living matter.” Now I can imagine living in the future where we've made living matter fully engineer-able, but tomorrow I have to go tell them about printing DNA from scratch and how difficult that is with the tools that we have.

What's interesting about these students is they represent part of a sustaining community that for the first time in the engineering of biology has begun to work on the problem of solving problems, not just the immediacy of the application, which is typically overdriving and very pressing in bio. Cure the disease, save the environment, do it right now. The problem of solving problems is the secret of how we sustain exponential improvements in our capacity to do stuff.  

It's easy to imagine a future where we have a distinct desktop DNA printer that's programmed with light and you can make any piece of DNA you want on your kitchen counter or your bench. Maybe you're doing biosynthesis of morphine in the yeast in your bread machine. To have personalized pharmaceutical companies. Maybe you're doing something else.

Well what do we wish for about this future where we've made living matter fully engineer-able? 

I have two wishes. One is it's a future of citizens and not consumers. Biology has a potential to realize distributed manufacturing which it does on nature on a massive scale. And that allows us to flip a trend which has been going on for the last century disempowering individuals.

The second wish I have it that when we think about ourselves we think beyond ourselves.  Apparently during my lifetime half of the animals on Earth are no longer on Earth collectively.  And to think about humans and biology without thinking about the rest of the world is insane.  

Drew Endy is a synthetic biologist and member of Bio-X at Stanford.